Anti-dsDNA antibodies in sarcoidosis
Identifieur interne : 002572 ( Main/Exploration ); précédent : 002571; suivant : 002573Anti-dsDNA antibodies in sarcoidosis
Auteurs : Ido Weinberg [Israël] ; Lena Vasiliev [Israël] ; Israel Gotsman [Israël]Source :
- Seminars in Arthritis and Rheumatism [ 0049-0172 ] ; 2000.
English descriptors
- KwdEn :
- Teeft :
- Antibody, Antidsdna antibodies, Antinuclear, Antinuclear antibodies, Average level, Biopsy, Chronic multisystem disorder, Clinical severity, Clinical symptoms, Definite diagnosis, Diffuse wheezes, Erythematosus, Gotsman, Granuloma, Hadassah, Hadassah university hospital, Heavy smoker, Hospitalization days, Immunoglobulin, Israel gotsman, Laboratory studies, Liver function tests, Lung disease, Lupus, Noncaseating, Noncaseating granuloma, Noncaseating granulomas, Normal limits, Normal subjects, Parotid glands, Physical examination, Rheum, Rheumatoid, Rheumatoid factor, Sarcoid, Sarcoid patients, Sarcoidosis, School hebrew university, Serological markers, Significant difference, Specific marker, Steroid, Steroid treatment, Systemic lupus erythematosus, Tissue biopsy, University hospital, Various antibodies.
Abstract
Background:Sarcoidosis is a chronic multisystem disorder characterized by an exaggerated cellular immune response to antigens with the production of various antibodies including rheumatoid factor and antinuclear antibodies (ANA). The prevalence and significance of antibodies to double-stranded DNA (anti-dsDNA) in sarcoid patients is unknown. The occurrence of anti-dsDNA antibodies is known to be a specific marker of systemic lupus erythematosus (SLE). Sarcoidosis can occur with SLE. It is unclear if anti-dsDNA antibodies in patients with sarcoidosis signify the eventual development of SLE.Objectives:To determine the prevalence of anti-dsDNA antibodies inpatients with sarcoidosis in a university hospital and their significance in predicting the diagnosis of associated SLE.Methods:In a retrospective study, 34 patient files with diagnosed sarcoidosis in a university hospital during a period of 15 years were reviewed for serological markers, including ANA, anti-dsDNA, and immunoglobulin and C3 levels. The occurrence of SLE in these patients also was evaluated.Results:ANA were positive in 10 of 34 of the patients screened. Two patientswith sarcoidosis had antibodies to dsDNA. C3 levels in these 34 patients were an average of 87.7 ± 25.3 mg/100 mL, which is within the normal range. IgG immunoglobulin levels were an average of 2,206 ± 999 mg/100 mL, which was above normal limits. The 2 patients who were positive for anti-dsDNA had normal C3 levels and SLE did not develop during a follow-up period of 10 to 15 years.Conclusions:Anti-dsDNA antibodies may occur in patients with sarcoidosis, but their presence does not predict the subsequent development of SLE.
Url:
DOI: 10.1016/S0049-0172(00)80019-0
Affiliations:
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Jerusalem</wicri:regionArea><wicri:noRegion>Hebrew University; Jerusalem</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Division ofMedicine, Hadassah University Hospital</wicri:regionArea><wicri:noRegion>Hadassah University Hospital</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Hadassah Medical School, Hebrew University; Jerusalem</wicri:regionArea><wicri:noRegion>Hebrew University; Jerusalem</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Israël</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Seminars in Arthritis and Rheumatism</title><title level="j" type="abbrev">YSARH</title><idno type="ISSN">0049-0172</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="328">328</biblScope><biblScope unit="page" to="331">331</biblScope></imprint><idno type="ISSN">0049-0172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0049-0172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-double-stranded DNA antibodies</term><term>antinuclear antibodies</term><term>hyperglobulinemia</term><term>sarcoidosis</term><term>systemic lupus erythematosus</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Antibody</term><term>Antidsdna antibodies</term><term>Antinuclear</term><term>Antinuclear antibodies</term><term>Average level</term><term>Biopsy</term><term>Chronic multisystem disorder</term><term>Clinical severity</term><term>Clinical symptoms</term><term>Definite diagnosis</term><term>Diffuse wheezes</term><term>Erythematosus</term><term>Gotsman</term><term>Granuloma</term><term>Hadassah</term><term>Hadassah university hospital</term><term>Heavy smoker</term><term>Hospitalization days</term><term>Immunoglobulin</term><term>Israel gotsman</term><term>Laboratory studies</term><term>Liver function tests</term><term>Lung disease</term><term>Lupus</term><term>Noncaseating</term><term>Noncaseating granuloma</term><term>Noncaseating granulomas</term><term>Normal limits</term><term>Normal subjects</term><term>Parotid glands</term><term>Physical examination</term><term>Rheum</term><term>Rheumatoid</term><term>Rheumatoid factor</term><term>Sarcoid</term><term>Sarcoid patients</term><term>Sarcoidosis</term><term>School hebrew university</term><term>Serological markers</term><term>Significant difference</term><term>Specific marker</term><term>Steroid</term><term>Steroid treatment</term><term>Systemic lupus erythematosus</term><term>Tissue biopsy</term><term>University hospital</term><term>Various antibodies</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:Sarcoidosis is a chronic multisystem disorder characterized by an exaggerated cellular immune response to antigens with the production of various antibodies including rheumatoid factor and antinuclear antibodies (ANA). The prevalence and significance of antibodies to double-stranded DNA (anti-dsDNA) in sarcoid patients is unknown. The occurrence of anti-dsDNA antibodies is known to be a specific marker of systemic lupus erythematosus (SLE). Sarcoidosis can occur with SLE. It is unclear if anti-dsDNA antibodies in patients with sarcoidosis signify the eventual development of SLE.Objectives:To determine the prevalence of anti-dsDNA antibodies inpatients with sarcoidosis in a university hospital and their significance in predicting the diagnosis of associated SLE.Methods:In a retrospective study, 34 patient files with diagnosed sarcoidosis in a university hospital during a period of 15 years were reviewed for serological markers, including ANA, anti-dsDNA, and immunoglobulin and C3 levels. The occurrence of SLE in these patients also was evaluated.Results:ANA were positive in 10 of 34 of the patients screened. Two patientswith sarcoidosis had antibodies to dsDNA. C3 levels in these 34 patients were an average of 87.7 ± 25.3 mg/100 mL, which is within the normal range. IgG immunoglobulin levels were an average of 2,206 ± 999 mg/100 mL, which was above normal limits. The 2 patients who were positive for anti-dsDNA had normal C3 levels and SLE did not develop during a follow-up period of 10 to 15 years.Conclusions:Anti-dsDNA antibodies may occur in patients with sarcoidosis, but their presence does not predict the subsequent development of SLE.</div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Weinberg, Ido" sort="Weinberg, Ido" uniqKey="Weinberg I" first="Ido" last="Weinberg">Ido Weinberg</name></noRegion><name sortKey="Gotsman, Israel" sort="Gotsman, Israel" uniqKey="Gotsman I" first="Israel" last="Gotsman">Israel Gotsman</name><name sortKey="Gotsman, Israel" sort="Gotsman, Israel" uniqKey="Gotsman I" first="Israel" last="Gotsman">Israel Gotsman</name><name sortKey="Gotsman, Israel" sort="Gotsman, Israel" uniqKey="Gotsman I" first="Israel" last="Gotsman">Israel Gotsman</name><name sortKey="Gotsman, Israel" sort="Gotsman, Israel" uniqKey="Gotsman I" first="Israel" last="Gotsman">Israel Gotsman</name><name sortKey="Gotsman, Israel" sort="Gotsman, Israel" uniqKey="Gotsman I" first="Israel" last="Gotsman">Israel Gotsman</name><name sortKey="Vasiliev, Lena" sort="Vasiliev, Lena" uniqKey="Vasiliev L" first="Lena" last="Vasiliev">Lena Vasiliev</name><name sortKey="Vasiliev, Lena" sort="Vasiliev, Lena" uniqKey="Vasiliev L" first="Lena" last="Vasiliev">Lena Vasiliev</name><name sortKey="Vasiliev, Lena" sort="Vasiliev, Lena" uniqKey="Vasiliev L" first="Lena" last="Vasiliev">Lena Vasiliev</name><name sortKey="Weinberg, Ido" sort="Weinberg, Ido" uniqKey="Weinberg I" first="Ido" last="Weinberg">Ido Weinberg</name><name sortKey="Weinberg, Ido" sort="Weinberg, Ido" uniqKey="Weinberg I" first="Ido" last="Weinberg">Ido Weinberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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